Andrew L. Cooksy

Professor, Chemical Physics
Associate Director, Computational Sciences Research Center

office: on sabbatical at MIT 2023-24
email: acooksy@sdsu.edu
Cooksy photo

Cooksy Group Page

Curriculum Vitae

  • B.A., chemistry and physics, Harvard College, 1984
  • Ph.D., chemistry, University of California, Berkeley, 1990 (Richard J. Saykally)
  • Postdoctoral Research Associate, Harvard-Smithsonian Center for Astrophysics (Patrick Thaddeus) and Harvard University Department of Chemistry (William Klemperer), 1990-1993
  • University of Mississippi Department of Chemistry and Biochemistry, 1993-1999
  • NSF CAREER Award recipient, 1995
  • San Diego State University Department of Chemistry and Biochemistry, 1999-
  • Visiting Scientist, Oxford University (John M. Brown), 2005-2006
  • Northrop-Grumman Excellence in Teaching Award, 2010
  • Senate Excellence in Teaching Award, SDSU College of Sciences, 2011
  • Visiting Scientist, MIT (William H. Green), 2012-2013

Recent Courses

Research Interests

[C5H7 ts]

Pentadienyl/cyclopentenyl transition state.
(image by C. Cheng, CS689)

Our work focuses on reactive intermediates in combustion and interstellar chemistry, as investigated by laser spectroscopy and computational quantum mechanics. Collaborative work has included studies of spectroscopic theory, chemical catalysis, and organometallic spectra and reactivity.

Molecular free radicals are crucial to the chemistry of combustion, the upper atmosphere, polymerization, and interstellar molecular clouds. We are interested in the physical and chemical properties of these molecules, particularly those containing conjugated π-electron systems, such as HC3O and C4H, because the delocalized orbitals can confer surprising dynamic and reactive properties to these systems.

High Resolution Spectroscopy of Free Radicals

In our experimental work, we search for new spectra of small hydrocarbon or other first-row element free radicals in the infrared regions of the spectrum in order to characterize these dynamic properties. Our mid-infrared quantum cascade laser spectrometer uses a 2-meter 20-pass White cell as the sample chamber. With this system we search for strong stretching transitions in the free radicals, and then probe the isomerization coordinate by examining hot band and combination band spectra to obtain measurements at high resolution of the interesting vibrational dynamics of these molecules. These studies were originally supported by one of the first NSF CAREER awards, and is currently funded by the Army Research Office.

lab photo
lab photo

Computational Studies of Free Radical Structures and Dynamics

We are engaged in concurrent ab initio computational studies of these and larger molecules to investigate the relative stability of the competing structures, and their effect on the chemistry. These ab initio calculations guide the laboratory measurements of the energy level structure, geometry, and chemistry of these molecules, as well as offering information for the kinetic models of the highly complex chemical environments found in combustion and interstellar space.

diagram

Previous work in our group along these lines included studies of the mechanisms behind the elctrocyclic ring-closure of cyclopentadienyl radical (C5H5) and the vibrational dynamics of cyclooctatetraenyl (C8H7), including its effective isomerization from one structure to another under specific vibrational excitations.

Recognizing the need for a general, easily mastered way to study these complex vibrational dynamics, we've recently published a protocol for the integration of the vibrational Schrödinger equation on an arbitrary potential energy surface. This work formed the doctoral work of Dong Xu, one of SDSU's first two PhD students in Computational Sciences, and now a professor at Idaho State University. PhD student Peter Zajac extended that work by implementing periodic boundary conditions and a powerful interpolation engine, allowing users to input point-wise PES maps without first resorting to analytical fits.

Organometallics

Current work with Prof. Doug Grotjahn strives to understand the activity of organometallic catalysts synthesized in his lab. To model the transformation of a π-complexed alkyne into vinylidene on one of these catalysts, we mapped the reaction surface of the complex in two dimensions, finding an unexpected parallel in our previous work on multiple minima on vibrational surfaces of free radicals. We are in the midst of an exhaustive analysis of a system that catalyzes the formation of aldehyde from alkyne and water, finding that Grotjahn's signature heterocyclic ligands play a major role in the dynamics by providing a basic chemical environment to stabilize the relocation of hydrogen atoms. This project is funded by the National Science Foundation.

We have also contributed to several studies by Prof. Hani Amouri of the CNRS (Centre National de la Recherche Scientifique) in Paris. Prof. Amouri assembles organometallic complexes, often with two or more metal atoms, in a search for novel optoelectronic materials and nanostructures. Our work has supported the interpretation of spectroscopic and x-ray data by modeling characteristics of the molecular orbitals and intramolecular interactions.

Bridging Experiment and Theory

NCO molecule

The complex interactions among the spin and orbital magnetic fields of unpaired electrons and the rotational, vibrational, and nuclear angular momenta in these molecules also means that we sometimes work at the limits of present spectroscopic theory. Work from a sabbatical with the late Prof. John M. Brown at Oxford University involved the first combined analysis of the lowest vibrational bending states in the NCO radical. NCO is a prototype example of the Renner-Teller effect, in this case the strong interaction between the two electronic states formed when the Π state symmetry of the linear is broken upon bending. To complete this analysis, we used third-order perturbation theory to derive additional contributions to the effective Hamiltonian, which is still growing after 70 years.

We gratefully acknowledge funding for past and current work from the Army Research Office, the National Science Foundation, the Petroleum Research Fund of the American Chemical Society, the Exxon Education Foundation, and the San Diego Foundation.

Books and Book Chapters

[textbook cover] [Elsevier text cover]

Recent Publications

  1. "Enhancing CO2 Reduction Efficiency on Cobalt Phthalocyanine via Axial Ligation,"
    Kang H., Staples-West A., Washington A., Turchiano C., Cooksy A., Huang J., Gu J.,
    Chem. Cat. Chem. 15, e202300576 (2023). (doi: 10.1002/cctc.202300576.)
  2. "Chiral C2-symmetric bis-thioureas as enzyme mimics in enantioselective Michael addition,"
    Cruz H., Servín F.A., Aguirre G., Pérez S., Madrigal D., Chávez D., Cooksy A.L., Somanathan R.,
    Chirality 34, 877-886 (2022). (doi: 10.1002/chir.23438.)
  3. "Enantiopure, luminescent, cyclometalated Ir(iii) complexes with N-heterocyclic carbene-naphthalimide chromophore: Design, vibrational circular dichroism and TD-DFT calculations,"
    Groué A., Montier-Sorkine E., Cheng Y., Rager M.N., Jean M., Vanthuyne N., Crassous J., Lopez A.C., Saavedra Moncada A., Barbieri A., Cooksy A.L., Amouri H.,
    Dalton Transactions 51, 2750-2759 (2022). (doi: 10.1039/d1dt04006e.)
  4. "Kinetic Stability of Si2C5H2 Isomer with A Planar Tetracoordinate Carbon Atom,"
    Krishnan Thirumoorthy, Vijayanand Chandrasekaran, Andrew L. Cooksy, Venkatesan S. Thimmakondu,
    Chemistry 3, 13-27 (2021). (doi: 10.3390/chemistry3010002.)
  5. "Origins of High Kinetic (E)-selectivity in Alkene Isomerization by a CpRu(PN) Catalyst; a Combined Experimental and Computational Approach,"
    Thomas C. Cao, Andrew L. Cooksy, and Douglas B. Grotjahn,
    ACS Catal. 10, 15250-15258 (2020). (doi: 10.1021/acscatal.0c03497.)
  6. "Unifying Mechanism Involving Electron Affinity of Conjugated Imine as Anti-Cancer Agents and Miscellaneous Drugs: Reactive Oxygen Species, Oxidative Stress, and Electron Transfer,"
    Peter Kovacic, Harrison Rojak Pearce, Andrew Cooksy, and Wil Weston,
    Scientia Ricerca 4, 38-51 (2020).
  7. "Si2C5H2 Isomers — Search Algorithms Versus Chemical Intuition,"
    Krishnan Thirumoorthy, Andrew Cooksy, and Venkatesan Samy Thimmakondu,
    Phys. Chem. Chem. Phys. 22, 5865-5872 (2020). (doi: 10.1039/C9CP06145B.)
  8. "Theoretical Studies of SiC4H2 Isomers Delineate Three Low-Lying Silylidenes Are Missing in the Laboratory,"
    Nisha Job, Amir Karton, Krishnan Thirumoorthy, Andrew L. Cooksy, and Venkatesan Samy Thimmakondu,
    J. Phys. Chem. A 124, 987-1002 (2020). (doi: 10.1021/acs.jpca.9b1174.)
  9. "Tuning Internal Strain in Metal—Organic Frameworks via Vapor Phase Infiltration for CO2 Reduction,"
    Jing Gu, Fan Yang, Wenhui Hu, Chongqing Yang, Margaret Patrick, Andrew L. Cooksy, Jian Zhang, Jeffery A. Aguiar, Cheng-cheng Fang, Yinghua Zhou, Ying Shirley Meng, Jier Huang,
    Angew. Chem. 59, 4572–4580 (2020). (doi: 10.1002/anie.202000022.)

M.S. Theses and Ph.D. Dissertations

  1. Amalia C. Lopez, M.S. 2023. Computational Modeling of Organo-Transition Metal Compounds.
  2. Pierre Winter, M.S. 2016. Computational analysis of the thermodynamics and kinetics of hydrocarbon radical intermediates.
  3. Peter Zajac, Ph.D. 2013. Globally Accessible Finite Element Method based Web-Solver for the Vibrational Schodinger Equation and its Application to HC3O Carbon Chain Free Radical, ZnCl2+ and Hydroxyacetaldehyde Vibrational Dynamics in Polyatomic Molecules and Free Radicals.
  4. Dong Xu, Ph.D. 2007. FEMvib, an Ab Initio Multi-Dimensional Solver for Probing Vibrational Dynamics in Polyatomic Molecules and Free Radicals.
  5. Christopher D. Uranga, M.S. 2007. Characterization of Spectrometers for Infrared Spectroscopy of Free Radicals.
  6. Raymond L. Lui, M.S. 2005. Computational Study of Aqueous Reactions in Vitamin E Regeneration.
  7. Christopher Hinton, M.S. 2004. Computational Study of Carbon Radicals: C9H9 and HCnO.
  8. Roger Wong, M.S. 2004. Construction and Characterization of an Infrared Laser Spectrometer for Free Radicals.
  9. Dong Xu, M.S. 2003. Ab Initio Study of The Torsional Motion in Tolane
  10. Claudia L. Parker, Ph.D. 2000. Ab Initio and Spectroscopic Examination of Butadienyl Free Radicals.
  11. Haibo Wang, M.S. 1996. Ab Initio Calculations and Spectroscopy of Free Radicals.

Download Adobe Reader

K-12 Outreach Programs Full Publications List Student Evaluations NSF bio (PDF)