New Synthetic Routes to Biologically Active Hydroquinones. A
Contribution to Larger Scale Research Projects.
Tom Cole, SDSU Chemistry
Abstract
Many substituted hydroquinones and quinones are biologically active.
However, their synthesis is difficult since there are relatively few
general methods to form these compounds. Recently we have developed
a general route forming these critical carbon-carbon bonds via
organoboranes. One application of these compounds is the inhibition
of neutral sphingomyelinase-C and D. This program involves a variety
of disciplines. The approaches, challenges and rewards of larger
scale collaborative research projects will be presented and discussed.