Facilities in the Department include:
The Department of Chemistry and Biochemistry has three Varian VNMRS
nuclear magnetic resonance (NMR) spectrometers:
- VNMRS 600 MHz, installed in Spring 2007, and generally dedicated to biomolecular studies;
- INOVA 500 MHz, allocated for specialized work such as variable-temperature and kinetics studies;
- VNMRS 400 MHz, installed in Fall 2006, the workhorse machine for all synthetic chemists in the department,
equipped with a sample changer for overnight use.
A complement of probes provides the ability to observe the resonances
F and all nuclei with resonance
frequencies between 31
P and 15
N. These probes
can perform all modern one- and multi-dimensional experiments that are
essential for chemical research. All of the spectrometers are capable
of indirect detection and are equipped with pulsed-field gradients.
The 500 and 400 MHz spectrometers have automated dual broadband probes
P) that can be
automatically tuned for any nucleus in these ranges and for any solvent.
The 600 and 500 MHz spectrometers have three channel
N) probes. The 500 MHz
spectrometer has a probe for triple or quadruple resonance work,
capable of simultaneous or single irradiation of 13
N, and 31
All probes have variable temperature capability.
The spectrometers are being
networked, allowing data to be remotely processed. Students routinely
acquire data on the 400 MHz spectrometers. In addition to
meeting the educational and research needs of the university, the NMR
facility provides analytical services for industry and other
educational institutions. Dr. LeRoy Lafferty is a full-time
administrator of this equipment.
Chair Carl Carrano and the Bruker X8 APEX
The Department is well-equipped for both small molecule and macromolecular structure determinations.
Small molecule work is carried out on a Bruker X8 APEX X-Ray Diffractometer, featuring
- Bruker's highest sensitivity (170 electrons/Mo photon)
CCD detector and an extremely fast readout rate (0.3 sec
at 5122 resolution),
- a short beam path for high intensity,
- the Kappa goniostat geometry,
- comprehensive control and structure determination software.
This diffractometer is housed in the Chemical Sciences Laboratory
Building, and serves the structure determination needs of the numerous
groups in organic and
synthesis in the Department.
students working on Macromolecular diffractometer|
(photo: Anna Quezada)
The SDSU Department of Chemistry & Biochemistry Macromolecular X-ray
Crystallography Facility consists of the following:
- Rigaku RU-H3R 18 kW rotating-anode x-ray generator,
- R-Axis IV++ image plate detector,
- Osmic Blue x-ray optics system,
- Oxford Cryosystems 700 Series Cryostream cryostat,
- Inverse phi sample mounting goniometer,
The 300 mm x 300 mm detector aperture offers high spatial resolution,
while the data recognition, based on photostimulated luminescence,
is capable of remarkably low background noise compared to CCD detectors,
allowing a dynamic range of nearly six orders of magnitude.
The use of dual plates permits the instrument to acquire exposures
and read out data simultaneously.
This lab houses several GC- and two HPLC-mass spectrometric systems,
available for highly precise quantitative and qualitative analysis
of complex samples. Among other projects, these systems are presently
engaged in a long-term study of effects of tobacco smoke in association
with the SDSU School of Public Health.
The Department of Chemistry and Biochemistry Machine Shop is managed by
Benno Spingler, who has extensive experience in fabrication
in both metal and wood. The shop occupies about 1600 sq. feet
of space and is equipped with two mills, a 13-inch lathe,
drill press, 22-inch bandsaw, horixontal bandsaw, and numerous
sheet metal and wood-working tools. An extensive metal stock
The space is also used for the repair and maintenance of our many
The Department of Chemistry and Biochemistry at SDSU provides a substantial inventory of modern
chemical instrumentation in support of teaching and research. Included are
systems for the performance of nearly all major types of chemical
separations; several GC- and two HPLC-mass spectrometric systems;
two FT infrared spectrometers; ultraviolet-visible
spectrometric instruments for both atomic and molecular emission and
absorption studies; electrochemical instrumentation for potentiometric,
voltammetric and coulometric measurements; radiochemical
instrumentation; and laser systems for spectroscopy. Several groups
have inert-atmosphere gloveboxes for conducting research on air- and
The departmental computer lab has 25 personal
computers (Mac and PC) for general use, and numerous research-grade
computers are housed in individual laboratories. Access is also
available to accounts at the San Diego Supercomputer Center
include full-time NMR, analytical
instrument, and electronics technicians
as well as a shop technician for machining, plastic working,
welding, and other fabrications needs.