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Somanathan photo

Ratnasamy Somanathan

Adjunct Professor
Organic Chemistry

Office: CSL 233
Office Phone: 619-594-5264
e-mail: somanath_at_sundown.sdsu.edu

Research Interests

My research interests are in developing new synthetic technologies leading to biologically active natural and unnatural products. Major programs include the synthesis of biologically active enamides (styrylamides) isolated from marine and microorganisms, and the development of methods leading to the enantioselective synthesis of beta-amino alcohols.

Selected Publications

  1. "2,2',6,6'-Tetrabromobiphenyl," Jesus Estrada, Gerrardo Aguirre, Ratnasamy Somanathan, Sylvain Bernes, Acta. Cryst., E62, 388-389, (2006).
  2. "(R)-(-)-[1-(Naphthyl)ethyl]salicyldimine," A. L. Iglesias, Gerrardo Aguirre, Miguel Parra-Hake, Ratnasamy Somanathan, Acta. Cryst., E62, 390-392, (2006).
  3. "A Study of Substituent Effects on the Enantioselective Trimethylsilylcyanation of Benzaldehyde Catalyzed by Schiff Base-Titanium(IV) Complexes," Angeles Gama, Lucia Z. Flores-Lopez, Gerardo Aguirre, Miguel Parra-Hake, Ratnasamy Somanathan, and Thomas Cole, Tetrahedron: Asymmetry 16, 1167-1174, 2005.
  4. "Transfer hydrogenation reduction of acetophenone catalyzed by Ru(II) and Rh(I) complexes with ligands derived from (1R,2R)-cyclohexane-1,2-diamine," Norma Aide Cortez, Celia Z. Flores Lopez, Ramon Rodriguez-Apodaca, Lucia Z. Flores-Lopez, Miguel Parra-Hake and Ratnasamy Somanathan. ARKIVOC VI, 162-171, (2005).
  5. "Mechanism of Mitochondrial Uncouplers, Inhibitors, and Toxins: Focus on Electron Transfer, Free Radicals, and Structure-Activity Relationships," Peter Kovacic, Robert S. Pozos, Ratnasamy Somanathan, Nandita Shangari, and Peter J. O'Brien. Current Medicinal Chemistry, 12, 2601-2623. (2005).
  6. "Neurotoxicity: The Broad Framework of Electron Transfer, Oxidative Stress and Protection by Antioxidants," Peter Kovacic and Ratnasamy Somanathan Central Nervous System Agents in Medicinal Chemistry, 5, 249-258, (2005).
  7. "Synthesis of Analogs of Amathamide A and Their Preliminary Antimicrobial Activity," Moises Ramires Osuna, Daniel Chavez, Lourdes Hernandez, Elias Molins, Ratnasamy Somanathan, Gerardo Aguirre, Molecules 10, 295-301, (2005).
  8. "Transfer hydrogenation reduction of acetophenone catalyzed by Ru(II) and Rh(I) complexes with ligands derived from (1R,2R)-cyclohexane-1,2-diamine," Norma Aide Cortez, Celia Z. Flores Lopez, Ramon Rodriguez-Apodaca, Lucia Z. Flores-Lopez, Miguel Parra-Hake and Ratnasamy Somanathan, ARKIVOC VI, 162-171 (2005).
  9. "A study of substituent effects on the enantioselective trimethylsilylcyanation of benzaldehyde catalyzed by chiral Schiff base-titanium(IV) complexes," Gama A, Flores-Lopez LZ, Aguirre G, Parra-Hake M, Somanathan R, Cole T, Tetrahedron-Asymmetry 16, 1167-1174 (2005).
  10. "New chiral Schiff base-Cu(II) complexes as cyclopropanation catalysts," Iglesias AL, Aguirre G, Somanathan R, Parra-Hake M, Polyhedron 23, 3051-3062 (2004).
  11. Ruthenium (II)-Assisted Asymmetric Hydrogen Transfer Reduction of Acetophenone Using Chiral Tridentate Phosphorous-containing Ligands Derived from (1R, R)-Diamineocyclohexane. Celia Z. Flores-Lopez, Lucia Z. Flores-Lopez, Gerardo Aguirre, Lars H. Hellberg, Miguel Parra-Hake, Ratnasamy Somanathan. J. Molecular Catalysis A Chemical 215, 73-79 (2004).
  12. Conformational Structures and Dynamics of Cis-N-Alkenyl Amides Lucina Gudalupe Sanchez Martir, Gerardo Aguirre Hernandez, A.L. Cooksy, Lars. H. Hellberg, Ratnasamy Somanathan, Felipe Ramirez Romero. J. Molecular Structure 691, 235-240 (2004).
  13. Oxidation of Sulfide to chiral sulfoxides using Schiff base-Vanadium (IV) complexes Angelese gama, Lucia Z.Flores-Lopez, Gerardo Aguirre, Miguel Parra-Hake, Lars H.Hellberg, Ratnasamy Somanathan ARKIVOC XI, 4-15 (2003).
  14. Mechanism of Glutamate Neurochemistry: Electron Transfer and Reactive Oxygen Species. Peter Kovacic, Ratnasamy Somanathan, Michelle Inzunza. Revista de la Sociedad Quimica de Mexico 47, 146-150 (2003).
  15. N-alkenyl amide rotational barriers by 2D EXSY NMR Gerardo Aguirre, R. Somanathan, Lars. H. Hellberg, Tammy J. Dwyer, Robert North. Mag. Reson. Chem. 41, 131-134 (2003).
  16. Asymmetric Synthesis of amathamides A and B: novel alkaloids isolated from Amathai Wilsoni Moises Ramirez Osuna, Gerardo Aguirre, R. Somanathan, Elias Molins. Tetrahedron: Asymmetry 13, 2261-2266 (2002).
  17. Steric Effects in the Design of Chiral Schiff Base-Titanium Complexes: New Catalyst for Asymmetric Trimethylsilylcyanation of Aldehydes. Angelese Gama, Lucia Z. Flores Lopez, Gerrado Aguirre, Miguel Parra-Hake, Ratnasamy Somanathan and Patrick J. Walsh. Tetrahedron: Asymmetry 13, 149-154 (2002).

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